Modelling electron interactions: a semi-rigorous method

We report total electron scattering cross sections (TCS) for SF6, SF5 CF3, and CF3I, molecules of interest to the plasma industry over the energy range from threshold to 2000 eV. We also report the total scattering cross sections for e-formaldehyde for which there are currently no theoretical or experimental results reported. The ionization cross sections for these targets are also estimated using the Deustch and Maerk formalism and are compared with Binary Encounter Bethe (BEB) data of Kim

A classification of the ground states and topological defects in a rotating two-component Bose-Einstein condensate

We classify the ground states and topological defects of a rotating two-component condensate when varying several parameters: the intracomponent coupling strengths, the intercomponent coupling strength and the particle numbers.No restriction is placed on the masses or trapping frequencies of the individual components. We present numerical phase diagrams which show the boundaries between the regions of coexistence, spatial separation and symmetry breaking. Defects such as triangular coreless vortex lattices, square coreless vortex lattices and giant skyrmions are classified. Various aspects of the phase diagrams are analytically justified thanks to a non-linear $\sigma$ model that describes the condensate in terms of the total density and a pseudo-spin representation

Combining intracellular selection with protein-fragment complementation to derive A interacting peptides

Aggregation of the β-amyloid (Aβ) peptide into toxic oligomers is considered the primary event in the pathogenesis of Alzheimer's disease. Previously generated peptides and mimetics designed to bind to amyloid fibrils have encountered problems in solubility, protease susceptibility and the population of small soluble toxic oligomers oligomers. We present a new method that opens the possibility of deriving new amyloid inhibitors. The intracellular protein-fragment complementation assay (PCA) approach uses a semi-rational design approach to generate peptides capable of binding to Aβ. Peptide libraries are based on Aβ regions responsible for instigating amyloidosis, with screening and selection occurring entirely inside Escherichia coli. Successfully selected peptides must therefore bind Aβ and recombine an essential enzyme while permitting bacterial cell survival. No assumptions are made regarding the mechanism of action for selected binders. Biophysical characterisation demonstrates that binding induces a noticeable reduction in amyloid. Therefore, this amyloid-PCA approach may offer a new pathway for the design of effective inhibitors against the formation of amyloid in general

Mass spectrometric analysis of small negative ions (e/m < 100) produced by Trichel pulse negative corona discharge fed by ozonised air

Mass spectrometric analysis of small negative ions (e/m < 100) produced by DC negative corona discharge in ozonised wet air both in flow and flow-stopped regimes was conducted at pressure of 30 kPa. The point-to-plain electrode system has been used. The yield of individual ions is strongly affected by trace concentrations of ozone in both regimes. Ozone concentration greater than 25 ppm is sufficient to completely suppress the appearance of O2- and a NO2- ion as well as theirs clusters in the mass spectra. The temporal increase in concentration of NO3- ions and NO3-.(H2O)n (n = 1, 2) hydrated clusters was observed in flow-stopped regime accompanied by reduction in yield of CO3- ion and its water clusters CO3-.(H2O)n (n = 1, 2), which otherwise are the dominant ions in flowing wet air free of ozone. In contrast the addition of ozone into the flow of wet air resulted in evident increase in abundance of the clusters CO3-.(H2O)n (n = 1, 2). This is an evidence of an active role of nitrous oxide produced in flow-stopped regime in sufficient amount. The measured electrical conductivity of drift region confirmed the role of additional dissociative attachment of electrons by ozone molecules as well as a formation of clusters of lower mobility with increasing ozone concentration in the discharge gap

Experimental Design at the Intersection of Mathematics, Science, and Technology in Grades K-6

Interdisciplinary courses, highlighting as they do the area(s) the disciplines have in common, often give the misperception of a single body of knowledge and/or way of knowing. However, discipline based courses often leave the equally mistaken notion that the disciplines have nothing in common. The task of the methods courses described in this paper is to reach an appropriate balance so that our pre-service elementary (K-6) teachers have a realistic perception of the independence and interdependence of mathematics and science. At the College of William and Mary each cohort of pre-service elementary teachers enrolls in mathematics and science methods courses taught in consecutive hours. Both instructors emphasize the importance of the content pedagogy unique to their disciplines such as strategies for teaching problem solving, computation, algebraic thinking, and proportional reasoning in mathematics and strategies for teaching students how to investigate and understand the concepts of science. The instructors model interdisciplinary instruction by collaboratively teaching common content pedagogy such as the use of technology, data analysis, and interpretation. Students also identify real-life application of the mathematical principles they are learning that can be applied to science. The concept of simultaneously teaching appropriately selected math and science skills are stressed. Given this approach students are not left with the notion that mathematics is the handmaid of science nor the notion that it is the queen of the sciences. Rather, they view mathematics as a co-equal partner

Using Technology as a Vehicle to Appropriately Integrate Mathematics and Science Instruction for the Middle School

At the College of William and Mary, pre-service middle school science and mathematics teachers enroll in their respective methods courses taught in the same time period. Both instructors emphasize the importance of the content pedagogy unique to their disciplines in their individual courses such as strategies for teaching problem solving, computation, proportional reasoning, algebraic and geometric thinking in mathematics, and strategies for teaching students how to investigate or design and conduct experiments in science. However, the two classes come together for sessions in which they examine the relationship of the two disciplines and the proper role of technology, both graphing calculator and computer, in their instruction Starting with resources such as Science in Seconds for Kids by Jean Potter [1], the science students collaborate with the math students to design and conduct brief experiments. The data generated is analyzed using spreadsheets and later graphing calculators. Various classes of mathematical curves are examined using data generated by sensors/probes and CBLs. Through this experience the pre-service teachers learn to work collaboratively with their colleagues on meaningful tasks, strengthening the effectiveness of all participants

Dissociative electron attachment to formamide

Formamide (HCONH2) is the smallest molecule with a peptide bond and has recently been observed in the interstellar medium (ISM), suggesting that it may be ubiquitous in star-forming regions. There is therefore considerable interest in the mechanisms by which this molecule may form. One method is electron induced chemistry within the icy mantles on the surface of dust grains. In particular it has been recently shown that functional group dependence exists in electron attachment processes giving rise to site selective fragmentation of molecules at the C-H, O-H and N-H bonds at energies well beyond the threshold for the breaking of any of these bonds allowing novel forms of chemistry that have little or no activation barriers, such as are necessary in the ISM. In this poster we present the results of resent studies on dissociative electron attachment (DEA) to formamide DEA using an improved version of a Velocity Map Imaging (VMI) spectrometer comprised of a magnetically collimated and low energy pulsed electron gun, a Faraday cup (to measure the incident current), an effusive molecular beam, a pulsed field ion extraction, a time of flight analyzer and a two-dimensional position sensitive detector consisting of microchannel plate and a phosphor screen. The VMI spectrometer measures the kinetic energy and angular distribution of the fragment anions produced in the dissociative electron attachment process. The kinetic energy measurements provide information on the internal energies of the fragment anions and determine the dissociation limits of the parent negative ion resonant states responsible for the dissociative electron attachment process. The angular distribution measurements provide the information about the symmetry of these negative ion resonant states. We shall present the details, results and conclusions of these measurements during the conference